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Image Search Results
Journal: Genome Research
Article Title: A common pattern of DNase I footprinting throughout the human mtDNA unveils clues for a chromatin-like organization
doi: 10.1101/gr.230409.117
Figure Lengend Snippet: Flow of mt-DGF analysis. ( A ) Distribution of raw mt-DGF lengths calculated for ENCODE samples. y -Axis represents length of each mt-DGF in nucleotides. ( B ) Conversion of a representative mt-DGF site from raw mt-DGF site data (black lines) collected from all analyzed samples to the final listed mt-DGF site (red line). Notice that for each mt-DGF, overlapping raw mt-DGFs were combined in all analyzed samples (for ENCODE and Roadmap, separately); the length of each combined mt-DGF was between the 5′ and 3′ nucleotide positions of the most proximal and distal overlapping raw DGFs, respectively. ( C ) Length distribution (in nucleotides; y -axis) of all final (combined) mt-DGF sites. ( D ) F -score graph of a representative mt-DGF site, which overlaps a well-known regulatory element—the light strand origin of replication (OriL): ( x -axis) mtDNA position; ( y -axis) calculated F -score; (black curve) mean F -score values, surrounded by their calculated SD (gray area), based on all ENCODE samples. ( E ) A flow chart of our mt-DGF analysis. The Venn diagram shows the actual number of common mt-DGF sites (i.e., identified in at least 90% of the samples) in the ENCODE and Roadmap data sets. The number of common sites whose mtDNA location overlapped between the two data sets is indicated.
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Techniques:
Journal: Genome Research
Article Title: A common pattern of DNase I footprinting throughout the human mtDNA unveils clues for a chromatin-like organization
doi: 10.1101/gr.230409.117
Figure Lengend Snippet: Evidence for tissue specificity in the mt-DGF pattern. PCO analysis of the Roadmap collection. ( A ) All Roadmap samples (“large” and “small” refer to large intestine and small intestine, respectively). ( B ) All samples from fetal day 97 (total = 12; skin = 7). Encircled are the human skin samples.
Article Snippet:
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